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Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads
The costimulatory receptor, CD28, synergizes with the T cell antigen receptor (TCR) to promote IL-2 production, cell survival and proliferation; yet the obligatory interdependence of TCR and CD28 signaling is not well understood. Upon TCR stimulation, Gads, a Grb2-family adaptor, bridges the interac...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8113088/ https://ncbi.nlm.nih.gov/pubmed/33931484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2001053 |
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