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In Vivo Significance of ITK-SLP-76 Interaction in Cytokine Production

In vitro data have suggested that activation of the inducible T-cell kinase (ITK) requires an interaction with the adaptor protein SLP-76. One means for this interaction involves binding of the ITK SH3 domain to the polyproline-rich (PR) region of SLP-76. However, the biological significance of this...

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Detalhes bibliográficos
Main Authors: Grasis, Juris A., Guimond, David M., Cam, Nicholas R., Herman, Krystal, Magotti, Paola, Lambris, John D., Tsoukas, Constantine D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897558/
https://ncbi.nlm.nih.gov/pubmed/20457812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01657-09
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