Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for hematological malignancies, due to graft-versus-leukemia (GVL) activity mediated by alloreactive donor T cells. However, graft-versus-host disease (GVHD) is also mediated by these cells. Here, we assessed the ef...

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Bibliographic Details
Published in:iScience
Main Authors: Mammadli, Mahinbanu, Huang, Weishan, Harris, Rebecca, Xiong, Hui, Weeks, Samuel, May, Adriana, Gentile, Teresa, Henty-Ridilla, Jessica, Waickman, Adam T., August, Avery, Bah, Alaji, Karimi, Mobin
Format: Artigo
Language:Inglês
Published: Elsevier 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024657/
https://ncbi.nlm.nih.gov/pubmed/33851101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102286
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