Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT

Allogeneic hematopoietic stem cell transplantation is a potentially curative procedure for many malignant diseases. Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. Donor T cells also contribute to graft-versus-host disease (GVHD), a debilitating and potentially fatal...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Mammadli, Mahinbanu, Huang, Weishan, Harris, Rebecca, Sultana, Aisha, Cheng, Ying, Tong, Wei, Pu, Jeffery, Gentile, Teresa, Dsouza, Shanti, Yang, Qi, Bah, Alaji, August, Avery, Karimi, Mobin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726260/
https://ncbi.nlm.nih.gov/pubmed/33324410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.593863
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