Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads

The costimulatory receptor, CD28, synergizes with the T cell antigen receptor (TCR) to promote IL-2 production, cell survival and proliferation; yet the obligatory interdependence of TCR and CD28 signaling is not well understood. Upon TCR stimulation, Gads, a Grb2-family adaptor, bridges the interac...

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Detaylı Bibliyografya
Yayımlandı:J Immunol
Asıl Yazarlar: Hallumi, Enas, Shalah, Rose, Lo, Wan-Lin, Corso, Jasmin, Oz, Ilana, Beach, Dvora, Wittman, Samuel, Isenberg, Amy, Sela, Meirav, Urlaub, Henning, Weiss, Arthur, Yablonski, Deborah
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113088/
https://ncbi.nlm.nih.gov/pubmed/33931484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2001053
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