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T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex

The cell surface receptor CD6 regulates T cell activation in both activating and inhibitory manners. The adaptor protein SLP-76 is recruited to the phosphorylated CD6 cytoplasmic Y662 residue during T cell activation, providing an activating signal to T cells. In this study, a biochemical approach i...

詳細記述

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書誌詳細
出版年:Mol Cell Biol
主要な著者: Breuning, Johannes, Brown, Marion H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440646/
https://ncbi.nlm.nih.gov/pubmed/28289074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00071-17
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