Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer’s disease (AD). Aβ clearance is mediated by macrophages, enzymatic degradation, perivascular drainage along the vascular basement membrane (VBM) and transcytosis across the blood–brai...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Acta Neuropathol Commun
Egile Nagusiak: Zhang, Xiao, O’Callaghan, Paul, Li, Honglian, Tan, Yingxia, Zhang, Ganlin, Barash, Uri, Wang, Xiaomin, Lannfelt, Lars, Vlodavsky, Israel, Lindahl, Ulf, Li, Jin-Ping
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2021
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111754/
https://ncbi.nlm.nih.gov/pubmed/33971986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01182-x
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