Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer’s disease (AD). Aβ clearance is mediated by macrophages, enzymatic degradation, perivascular drainage along the vascular basement membrane (VBM) and transcytosis across the blood–brai...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Acta Neuropathol Commun
Päätekijät: Zhang, Xiao, O’Callaghan, Paul, Li, Honglian, Tan, Yingxia, Zhang, Ganlin, Barash, Uri, Wang, Xiaomin, Lannfelt, Lars, Vlodavsky, Israel, Lindahl, Ulf, Li, Jin-Ping
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2021
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111754/
https://ncbi.nlm.nih.gov/pubmed/33971986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01182-x
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