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Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells
Heparan sulfate (HS) mediates the activity of various growth factors including TGF‐β. Heparanase is an endo‐glucuronidase that specifically cleaves and modifies HS structure. In this study, we examined the effect of heparanase expression on TGF‐β1‐dependent signaling activities. We found that overex...
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| Publicado no: | FEBS Open Bio |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5337900/ https://ncbi.nlm.nih.gov/pubmed/28286736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12190 |
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