Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer’s disease (AD). Aβ clearance is mediated by macrophages, enzymatic degradation, perivascular drainage along the vascular basement membrane (VBM) and transcytosis across the blood–brai...

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Detaylı Bibliyografya
Yayımlandı:Acta Neuropathol Commun
Asıl Yazarlar: Zhang, Xiao, O’Callaghan, Paul, Li, Honglian, Tan, Yingxia, Zhang, Ganlin, Barash, Uri, Wang, Xiaomin, Lannfelt, Lars, Vlodavsky, Israel, Lindahl, Ulf, Li, Jin-Ping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2021
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111754/
https://ncbi.nlm.nih.gov/pubmed/33971986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01182-x
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