Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer’s disease (AD). Aβ clearance is mediated by macrophages, enzymatic degradation, perivascular drainage along the vascular basement membrane (VBM) and transcytosis across the blood–brai...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Neuropathol Commun
Auteurs principaux: Zhang, Xiao, O’Callaghan, Paul, Li, Honglian, Tan, Yingxia, Zhang, Ganlin, Barash, Uri, Wang, Xiaomin, Lannfelt, Lars, Vlodavsky, Israel, Lindahl, Ulf, Li, Jin-Ping
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111754/
https://ncbi.nlm.nih.gov/pubmed/33971986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01182-x
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