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Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases

Kynurenine-3-monooxygenase (KMO) is an important therapeutic target for several brain disorders that has been extensively studied in recent years. Potent inhibitors towards KMO have been developed and tested within different disease models, showing great therapeutic potential, especially in models o...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arch Biochem Biophys
Prif Awduron: Zhang, Shaowei, Collier, Mary E.W., Heyes, Derren J., Giorgini, Flaviano, Scrutton, Nigel S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111166/
https://ncbi.nlm.nih.gov/pubmed/33275878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2020.108702
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