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Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis

BACKGROUND: Activation of mTORC1 plays a significant role in cancer development and progression. However, the metabolic mechanisms to sustain mTORC1 activation of cancer cells within stressed environments are still under-appreciated. We recently revealed high autophagy activity in tumour cells with...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Wang, Chenran, Haas, Michael A., Yeo, Syn Kok, Paul, Ritama, Yang, Fuchun, Vallabhapurapu, Subrahmanya, Qi, Xiaoyang, Plas, David R., Guan, Jun-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110959/
https://ncbi.nlm.nih.gov/pubmed/33723393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-021-01294-0
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