Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation

BACKGOUND: The mechanistic target of rapamycin complex 1 (mTORC1) is important in the development and progression of many cancers. Targeted cancer therapy using mTORC1 inhibitors is used for treatment of cancers; however, their clinical efficacies are still limited. METHODS: We recently created a ne...

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Detalles Bibliográficos
Publicado en:Br J Cancer
Main Authors: Yang, Fuchun, Sun, Shaogang, Wang, Chenran, Haas, Michael, Yeo, Syn, Guan, Jun-Lin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7283252/
https://ncbi.nlm.nih.gov/pubmed/32336756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0839-1
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