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Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells
Although mTORC1 negatively regulates autophagy in cultured cells, how autophagy impacts mTORC1 signaling, in particular in vivo, is less clear. Here we show that autophagy supports mTORC1 hyperactivation in NSCs lacking Tsc1, thereby promoting defects in NSC maintenance, differentiation, tumourigene...
Shranjeno v:
| izdano v: | Nat Metab |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7311104/ https://ncbi.nlm.nih.gov/pubmed/32577608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0137-5 |
| Oznake: |
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