TAMI-35. AUTOPHAGY MEDIATED LIPID CATABOLISM FACILITATES GLIOMA PROGRESSION TO OVERCOME BIOENERGETIC CRISIS

Activation of mTORC1 plays a significant role in cancer development and progression. However, the metabolic mechanisms to sustain mTORC1 activation in stressed cancer cells are still underappreciated. Autophagy, one downstream process of mTORC1, is proposed to be suppressed under the condition of mT...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Wang, Chenran, Haas, Michael, Yeo, Syn, Paul, Ritama, Yang, Fuchun, Vallabhapurapu, Subrahmanya, Qi, Xiaoyang, Plas, David R, Guan, Jun-Lin
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651293/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.923
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