TAMI-36. CONNEXIN 43 BLOCKADE INHIBITS PROLIFERATION IN IDH1-MUTANT GLIOMA CELLS

IDH1-mutant gliomas are characteristically sensitive to NAD+ depletion. It is known that NAD+ can move between cells through gap junctions, which provides an opportunity for treatments that prevent NAD+ sharing across tumor cells, effectively decreasing available NAD+. Previous studies have also sho...

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Vydáno v:Neuro Oncol
Hlavní autoři: Melamed, Lisa, Lee, Christine, Nagashima, Hiroaki, Miller, Julie, Wakimoto, Hiroaki, Cahill, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651625/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.924
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