TAMI-42. H3K27M MUTANT GLIOMAS HIJACK A CONSERVED AND CRITICAL METABOLIC PATHWAY USED BY IDH1 MUTANT GLIOMAS TO MAINTAIN THEIR PREFERRED EPIGENETIC STATE

H3K27M-midline gliomas are fatal tumors that mainly harbor H3.3K27M mutations resulting in global H3K27me3 reduction that impacts neuroglial-differentiation. However, the exact mechanisms by which H3.3K27M mutations promote cancer are poorly understood. Metabolic reprogramming is a hallmark of cance...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Chung, Chan, Sweha, Stefan, Pratt, Drew, Tamrazi, Benita, Panwalkar, Pooja, Banda, Adam, Bayliss, Jill, Hawes, Debra, Yang, Fusheng, Lee, Ho-Joon, Shan, Mengrou, Cieslik, Marcin, Qin, Tingting, Werner, Christian, Wahl, Daniel, Lyssiotis, Costas, Yadav, Viveka Nand, Koschmann, Carl, Chinnaiyan, Arul, Blumul, Stefan, Judkins, Alexander, Venneti, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651402/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.930
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