Integrated metabolic and epigenomic reprograming by H3K27M mutations in diffuse intrinsic pontine gliomas

H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments. They mainly harbor H3.3K27M mutations resulting in H3K27me3 reduction. Integrated analysis in H3.3K27M-cells, tumors and in vivo imaging in patients showed enhanced glycolysis, glutaminolysis, and TCA cycle metabolism wi...

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Pubblicato in:Cancer Cell
Autori principali: Chung, Chan, Sweha, Stefan R., Pratt, Drew, Tamrazi, Benita, Panwalkar, Pooja, Banda, Adam, Bayliss, Jill, Hawes, Debra, Yang, Fusheng, Lee, Ho-Joon, Shan, Mengrou, Cieslik, Marcin, Qin, Tingting, Werner, Christian K., Wahl, Daniel R., Lyssiotis, Costas A., Bian, Zhiguo, Shotwell, J. Brad, Yadav, Viveka Nand, Koschmann, Carl J., Chinnaiyan, Arul M., Blüml, Stefan, Judkins, Alexander R., Venneti, Sriram
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494613/
https://ncbi.nlm.nih.gov/pubmed/32795401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.07.008
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