Integrated metabolic and epigenomic reprograming by H3K27M mutations in diffuse intrinsic pontine gliomas

H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments. They mainly harbor H3.3K27M mutations resulting in H3K27me3 reduction. Integrated analysis in H3.3K27M-cells, tumors and in vivo imaging in patients showed enhanced glycolysis, glutaminolysis, and TCA cycle metabolism wi...

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Publicado no:Cancer Cell
Main Authors: Chung, Chan, Sweha, Stefan R., Pratt, Drew, Tamrazi, Benita, Panwalkar, Pooja, Banda, Adam, Bayliss, Jill, Hawes, Debra, Yang, Fusheng, Lee, Ho-Joon, Shan, Mengrou, Cieslik, Marcin, Qin, Tingting, Werner, Christian K., Wahl, Daniel R., Lyssiotis, Costas A., Bian, Zhiguo, Shotwell, J. Brad, Yadav, Viveka Nand, Koschmann, Carl J., Chinnaiyan, Arul M., Blüml, Stefan, Judkins, Alexander R., Venneti, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494613/
https://ncbi.nlm.nih.gov/pubmed/32795401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.07.008
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