TAMI-53. THE ONCOMETABOLITE D-2HG INDUCE INFLAMMATORY ASTROGLIOSIS CAUSING NEUROTOXICITY AND SEIZURES IN IDH MUTATED GLIOMA

The role of tumor-associated astrocytes in the microenvironment of glioma has long been underestimated but is moving into the focus of current research. We explored the role of reactive astrocytes in IDH-mutated glioma using RNA-sequencing of purified astrocytes and microglia and single-nucleus RNA-...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Behringer, Simon, Ravi, Vidhya, Joseph, Kevin, Beck, Juergen, Schnell, Oliver, Heiland, Dieter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650903/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.940
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