TAMI-20. POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITION SEQUESTERS NAD+ TO POTENTIATE THE METABOLIC LETHALITY OF ALKYLATING CHEMOTHERAPY IN IDH MUTANT TUMOR CELLS

Mutations in IDH1 or IDH2 characterize the majority of diffuse infiltrative gliomas of younger adulthood. DNA alkylator chemotherapy has proven to be an effective treatment for IDH mutant glioma, yet recurrences remain frequent and improved treatments are needed. Upon exposure of cancer cells to DNA...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Nagashima, Hiroaki, Lee, Christine, Tateishi, Kensuke, Higuchi, Fumi, Subramanian, Megha, Rafferty, Seamus, Melamed, Lisa, Miller, Julie, Wakimoto, Hiroaki, Cahill, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650933/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.909
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