CBMT-47. MODULATION OF NAD PATHWAYS AS A THERAPEUTIC STRATEGY FOR TARGETING IDH MUTANT GLIOMA

BACKGROUND: IDH mutant tumors exhibit an altered metabolic state which may be exploited for use as a novel therapeutic approach. Our previous work has shown the IDH mutant cancer survival is dependent on the biosynthetic enzyme, nicotinamide phosphoribosyltransferase (NAMPT), for the production of n...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Miller, Julie, Nagashima, Hiroaki, Fink, Alexandria, Tateishi, Kensuke, Wakimoto, Hiroaki, Banagis, Jack, Cahill, Daniel
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Cell Biology and Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846952/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.169
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