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Contribution of T Cell Receptor Alpha and Beta CDR3, MHC Typing, V and J Genes to Peptide Binding Prediction

INTRODUCTION: Predicting the binding specificity of T Cell Receptors (TCR) to MHC-peptide complexes (pMHCs) is essential for the development of repertoire-based biomarkers. This affinity may be affected by different components of the TCR, the peptide, and the MHC allele. Historically, the main eleme...

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Pubblicato in:Front Immunol
Autori principali: Springer, Ido, Tickotsky, Nili, Louzoun, Yoram
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8107833/
https://ncbi.nlm.nih.gov/pubmed/33981311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.664514
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