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Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions
Affinity maturation occurs through two selection processes: the choice of appropriate clones (clonal selection), and the internal evolution within clones, induced by somatic hyper-mutations, where high affinity mutants are selected for. When a final population of immunoglobulin sequences is observed...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3775539/ https://ncbi.nlm.nih.gov/pubmed/24062742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00274 |
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