Analyzing the CDR3 Repertoire with respect to TCR—Beta Chain V-D-J and V-J Rearrangements in Peripheral T Cells using HTS

V-D-J rearrangement of the TCR—beta chain follows the 12/23 rule and the beyond 12/23 restriction. Currently, the proportion and characteristics of TCR—beta chain V—J rearrangement is unclear. We used high-throughput sequencing to compare and analyze TCR—beta chain V-J rearrangement and V-D-J rearra...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ma, Long, Yang, Liwen, Bin Shi, He, Xiaoyan, Peng, Aihua, Li, Yuehong, Zhang, Teng, Sun, Suhong, Ma, Rui, Yao, Xinsheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941575/
https://ncbi.nlm.nih.gov/pubmed/27404392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29544
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