Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in inflammatory disorders like atherosclerosis, obesity, multiple sclerosis and sepsis. Targeting intracellular metabolism is considered as an approach to...

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Опубликовано в: :Front Immunol
Главные авторы: Verberk, Sanne G. S., van der Zande, Hendrik J. P., Baardman, Jeroen, de Goede, Kyra E., Harber, Karl J., Keuning, Eelco D., Lambooij, Joost M., Otto, Frank, Zawistowska-Deniziak, Anna, de Vries, Helga E., de Winther, Menno P. J., Guigas, Bruno, Van den Bossche, Jan
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2021
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8107722/
https://ncbi.nlm.nih.gov/pubmed/33981315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.669920
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