Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in inflammatory disorders like atherosclerosis, obesity, multiple sclerosis and sepsis. Targeting intracellular metabolism is considered as an approach to...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Verberk, Sanne G. S., van der Zande, Hendrik J. P., Baardman, Jeroen, de Goede, Kyra E., Harber, Karl J., Keuning, Eelco D., Lambooij, Joost M., Otto, Frank, Zawistowska-Deniziak, Anna, de Vries, Helga E., de Winther, Menno P. J., Guigas, Bruno, Van den Bossche, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8107722/
https://ncbi.nlm.nih.gov/pubmed/33981315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.669920
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