Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in inflammatory disorders like atherosclerosis, obesity, multiple sclerosis and sepsis. Targeting intracellular metabolism is considered as an approach to...

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Pubblicato in:Front Immunol
Autori principali: Verberk, Sanne G. S., van der Zande, Hendrik J. P., Baardman, Jeroen, de Goede, Kyra E., Harber, Karl J., Keuning, Eelco D., Lambooij, Joost M., Otto, Frank, Zawistowska-Deniziak, Anna, de Vries, Helga E., de Winther, Menno P. J., Guigas, Bruno, Van den Bossche, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8107722/
https://ncbi.nlm.nih.gov/pubmed/33981315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.669920
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