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Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication

The initiation of DNA replication involves cell cycle-dependent assembly and disassembly of protein complexes, including the Origin Recognition Complex (ORC) and CDC6 AAA+ ATPases. We report that multiple short linear protein motifs (SLiMs) within intrinsically disordered regions (IDRs) in ORC1 and...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Hossain, Manzar, Bhalla, Kuhulika, Stillman, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106667/
https://ncbi.nlm.nih.gov/pubmed/33761311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.03.003
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