Structural insights into integrin α(5)β(1) opening by fibronectin ligand

Integrin α(5)β(1) is a major fibronectin receptor critical for cell migration. Upon complex formation, fibronectin and α(5)β(1) undergo conformational changes. While this is key for cell-tissue connections, its mechanism is unknown. Here, we report cryo–electron microscopy structures of native human...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Schumacher, Stephanie, Dedden, Dirk, Nunez, Roberto Vazquez, Matoba, Kyoko, Takagi, Junichi, Biertümpfel, Christian, Mizuno, Naoko
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8104898/
https://ncbi.nlm.nih.gov/pubmed/33962943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe9716
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