Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients

Most lung transplantation immunosuppression regimens include tacrolimus. Single nucleotide polymorphisms (SNPs) in genes important to tacrolimus bioavailability (ABCB1) and clearance (CYP3A4 and CYP3A5) are associated with differences in tacrolimus pharmacokinetics. We hypothesized that polymorphism...

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Библиографические подробности
Опубликовано в: :Clin Transplant
Главные авторы: Calabrese, Daniel R., Boettger, Rebecca, Dewey, Katherine, Hui, Christine, Torgerson, Dara, Chong, Tiffany, Faust, Hilary, Rajalingam, Raja, Hays, Steven R., Golden, Jeff A., Kukreja, Jasleen, Singer, Jonathan P., Greenland, John R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103920/
https://ncbi.nlm.nih.gov/pubmed/29920787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ctr.13332
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