Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients

Most lung transplantation immunosuppression regimens include tacrolimus. Single nucleotide polymorphisms (SNPs) in genes important to tacrolimus bioavailability (ABCB1) and clearance (CYP3A4 and CYP3A5) are associated with differences in tacrolimus pharmacokinetics. We hypothesized that polymorphism...

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Vydáno v:Clin Transplant
Hlavní autoři: Calabrese, Daniel R., Boettger, Rebecca, Dewey, Katherine, Hui, Christine, Torgerson, Dara, Chong, Tiffany, Faust, Hilary, Rajalingam, Raja, Hays, Steven R., Golden, Jeff A., Kukreja, Jasleen, Singer, Jonathan P., Greenland, John R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103920/
https://ncbi.nlm.nih.gov/pubmed/29920787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ctr.13332
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