Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients

Most lung transplantation immunosuppression regimens include tacrolimus. Single nucleotide polymorphisms (SNPs) in genes important to tacrolimus bioavailability (ABCB1) and clearance (CYP3A4 and CYP3A5) are associated with differences in tacrolimus pharmacokinetics. We hypothesized that polymorphism...

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Detalhes bibliográficos
Publicado no:Clin Transplant
Main Authors: Calabrese, Daniel R., Boettger, Rebecca, Dewey, Katherine, Hui, Christine, Torgerson, Dara, Chong, Tiffany, Faust, Hilary, Rajalingam, Raja, Hays, Steven R., Golden, Jeff A., Kukreja, Jasleen, Singer, Jonathan P., Greenland, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103920/
https://ncbi.nlm.nih.gov/pubmed/29920787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ctr.13332
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