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Promoter G-quadruplex folding precedes transcription and is controlled by chromatin

BACKGROUND: Four-stranded G-quadruplexes (G4s) are DNA secondary structures in the human genome that are primarily found in active promoters associated with elevated transcription. Here, we explore the relationship between the folding of promoter G4s, transcription and chromatin state. RESULTS: Tran...

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Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Shen, Jiazhen, Varshney, Dhaval, Simeone, Angela, Zhang, Xiaoyun, Adhikari, Santosh, Tannahill, David, Balasubramanian, Shankar
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103603/
https://ncbi.nlm.nih.gov/pubmed/33962653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02346-7
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