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Promoter G-quadruplex folding precedes transcription and is controlled by chromatin

BACKGROUND: Four-stranded G-quadruplexes (G4s) are DNA secondary structures in the human genome that are primarily found in active promoters associated with elevated transcription. Here, we explore the relationship between the folding of promoter G4s, transcription and chromatin state. RESULTS: Tran...

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Bibliographische Detailangaben
Veröffentlicht in:Genome Biol
Hauptverfasser: Shen, Jiazhen, Varshney, Dhaval, Simeone, Angela, Zhang, Xiaoyun, Adhikari, Santosh, Tannahill, David, Balasubramanian, Shankar
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103603/
https://ncbi.nlm.nih.gov/pubmed/33962653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02346-7
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