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DOCK8 expression in Treg cells maintains their stability and limits contact hypersensitivity

Chronic dermatitis is a hallmark of Dedicator of cytokinesis 8 (DOCK8) deficiency. The migration of DOCK8-deficient T cells to the skin and their survival there has been reported to be defective. Surprisingly, we found that Dock8(−/−) mice demonstrated an exaggerated contact hypersensitivity (CHS) r...

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Bibliografiska uppgifter
I publikationen:J Invest Dermatol
Huvudupphovsmän: Wilkie, Hazel, Janssen, Erin, Leyva-Castillo, Juan Manuel, Geha, Raif S
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102650/
https://ncbi.nlm.nih.gov/pubmed/33171169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.09.027
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