DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs

Patients deficient in the guanine nucleotide exchange factor DOCK8 have decreased numbers and impaired in vitro function of Tregs and make autoantibodies, but they seldom develop autoimmunity. We show that, similarly, Dock8(–/–) mice have decreased numbers and impaired in vitro function of Tregs but...

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Detalhes bibliográficos
Publicado no:JCI Insight
Principais autores: Janssen, Erin, Kumari, Sudha, Tohme, Mira, Ullas, Sumana, Barrera, Victor, Tas, Jeroen M.J., Castillo-Rama, Marcela, Bronson, Roderick T., Usmani, Shariq M., Irvine, Darrell J., Mempel, Thorsten R., Geha, Raif S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841868/
https://ncbi.nlm.nih.gov/pubmed/28978806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94298
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