DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs

Patients deficient in the guanine nucleotide exchange factor DOCK8 have decreased numbers and impaired in vitro function of Tregs and make autoantibodies, but they seldom develop autoimmunity. We show that, similarly, Dock8(–/–) mice have decreased numbers and impaired in vitro function of Tregs but...

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Vydáno v:JCI Insight
Hlavní autoři: Janssen, Erin, Kumari, Sudha, Tohme, Mira, Ullas, Sumana, Barrera, Victor, Tas, Jeroen M.J., Castillo-Rama, Marcela, Bronson, Roderick T., Usmani, Shariq M., Irvine, Darrell J., Mempel, Thorsten R., Geha, Raif S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841868/
https://ncbi.nlm.nih.gov/pubmed/28978806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94298
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