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Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism
Overexpression and aggregation of α-synuclein (ASyn) are linked to the onset and pathology of Parkinson’s disease and related synucleinopathies. Elevated levels of the stress-induced chaperone Hsp70 protect against ASyn misfolding and ASyn-driven neurodegeneration in cell and animal models, yet ther...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8102405/ https://ncbi.nlm.nih.gov/pubmed/33798554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100613 |
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