Загрузка...
Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism
Overexpression and aggregation of α-synuclein (ASyn) are linked to the onset and pathology of Parkinson’s disease and related synucleinopathies. Elevated levels of the stress-induced chaperone Hsp70 protect against ASyn misfolding and ASyn-driven neurodegeneration in cell and animal models, yet ther...
Сохранить в:
| Опубликовано в: : | J Biol Chem |
|---|---|
| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2021
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8102405/ https://ncbi.nlm.nih.gov/pubmed/33798554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100613 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|