Stable α-Synuclein Oligomers Strongly Inhibit Chaperone Activity of the Hsp70 System by Weak Interactions with J-domain Co-chaperones

α-Synuclein aggregation and accumulation in Lewy bodies are implicated in progressive loss of dopaminergic neurons in Parkinson disease and related disorders. In neurons, the Hsp70s and their Hsp40-like J-domain co-chaperones are the only known components of chaperone network that can use ATP to con...

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Autores principales: Hinault, Marie-Pierre, Cuendet, America Farina Henriquez, Mattoo, Rayees U. H., Mensi, Mounir, Dietler, Giovanni, Lashuel, Hilal A., Goloubinoff, Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992251/
https://ncbi.nlm.nih.gov/pubmed/20847048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127753
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