Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α-synuclein complex by Hip

The ATP-dependent protein chaperone heat-shock protein 70 (Hsp70) displays broad anti-aggregation functions and has a critical function in preventing protein misfolding pathologies. According to in vitro and in vivo models of Parkinson's disease (PD), loss of Hsp70 activity is associated with n...

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Main Authors: Roodveldt, Cintia, Bertoncini, Carlos W, Andersson, August, van der Goot, Annemieke T, Hsu, Shang-Te, Fernández-Montesinos, Rafael, de Jong, Jannie, van Ham, Tjakko J, Nollen, Ellen A, Pozo, David, Christodoulou, John, Dobson, Christopher M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790486/
https://ncbi.nlm.nih.gov/pubmed/19875982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.298
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