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Anti-tumor activity of NLG207 (formerly CRLX101) in combination with enzalutamide in preclinical prostate cancer models

Effective treatments for patients with mCRPC following disease progression on enzalutamide is currently an unmet clinical need. Simultaneous inhibition of the HIF-1α and AR pathways has been shown to overcome enzalutamide resistance in vitro. Combination treatment with NLG207, a nanoparticle-drug co...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Mol Cancer Ther
Päätekijät: Schmidt, Keith T., Chau, Cindy H., Strope, Jonathan D., Huitema, Alwin D. R., Sissung, Tristan M., Price, Douglas K., Figg, William D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102325/
https://ncbi.nlm.nih.gov/pubmed/33632874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0228
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