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Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma
Camptothecin (CPT), a potent inhibitor of topoisomerase I and HIF-1α, failed to demonstrate utility as an anti-cancer agent in early clinical trial investigations, primarily due to limited clinical activity and significant toxicity attributable to unfavorable physicochemical properties (e.g. low pla...
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| Publicado no: | J Pharm Biomed Anal |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7068816/ https://ncbi.nlm.nih.gov/pubmed/31927166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2019.113073 |
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