Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma

Camptothecin (CPT), a potent inhibitor of topoisomerase I and HIF-1α, failed to demonstrate utility as an anti-cancer agent in early clinical trial investigations, primarily due to limited clinical activity and significant toxicity attributable to unfavorable physicochemical properties (e.g. low pla...

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Veröffentlicht in:J Pharm Biomed Anal
Hauptverfasser: Schmidt, Keith T., Peer, Cody J., Huitema, Alwin D. R., Williams, Monique D., Wroblewski, Susan, Schellens, Jan H. M., Madan, Ravi A., Figg, William D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068816/
https://ncbi.nlm.nih.gov/pubmed/31927166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2019.113073
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