Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

PURPOSE: NLG207 (formerly CRLX101) is a nanoparticle–drug conjugate (NDC) of the potent topoisomerase I inhibitor, camptothecin (CPT). The present study sought to characterize the complex pharmacokinetics (PK) of NLG207 and better describe CPT release from nanoparticles using a population PK (popPK)...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Chemother Pharmacol
Hauptverfasser: Schmidt, Keith T., Huitema, Alwin D. R., Dorlo, Thomas P. C., Peer, Cody J., Cordes, Lisa M., Sciuto, Linda, Wroblewski, Susan, Pommier, Yves, Madan, Ravi A., Thomas, Anish, Figg, William D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2020
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515962/
https://ncbi.nlm.nih.gov/pubmed/32897402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04134-9
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