Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

PURPOSE: NLG207 (formerly CRLX101) is a nanoparticle–drug conjugate (NDC) of the potent topoisomerase I inhibitor, camptothecin (CPT). The present study sought to characterize the complex pharmacokinetics (PK) of NLG207 and better describe CPT release from nanoparticles using a population PK (popPK)...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Schmidt, Keith T., Huitema, Alwin D. R., Dorlo, Thomas P. C., Peer, Cody J., Cordes, Lisa M., Sciuto, Linda, Wroblewski, Susan, Pommier, Yves, Madan, Ravi A., Thomas, Anish, Figg, William D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515962/
https://ncbi.nlm.nih.gov/pubmed/32897402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04134-9
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