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Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration

The asymmetric distribution of microtubule (MT) dynamics in migrating cells is important for cell polarization, yet the underlying regulatory mechanisms remain underexplored. Here, we addressed this question by studying the role of the MT depolymerase, MCAK (mitotic centromere-associated kinesin), i...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Zong, Hailing, Hazelbaker, Mark, Moe, Christina, Ems-McClung, Stephanie C., Hu, Ke, Walczak, Claire E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101467/
https://ncbi.nlm.nih.gov/pubmed/33566676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-05-0301
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