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Full-Length Dimeric MCAK Is a More Efficient Microtubule Depolymerase than Minimal Domain Monomeric MCAK

MCAK belongs to the Kinesin-13 family, whose members depolymerize microtubules rather than translocate along them. We defined the minimal functional unit of MCAK as the catalytic domain plus the class specific neck (MD-MCAK), which is consistent with previous reports. We used steady-state ATPase kin...

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Detalhes bibliográficos
Main Authors: Hertzer, Kathleen M., Ems-McClung, Stephanie C., Kline-Smith, Susan L., Lipkin, Thomas G., Gilbert, Susan P., Walczak, Claire E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356581/
https://ncbi.nlm.nih.gov/pubmed/16291860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-08-0821
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