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The Interplay of the N- and C-Terminal Domains of MCAK Control Microtubule Depolymerization Activity and Spindle Assembly

Spindle assembly and accurate chromosome segregation require the proper regulation of microtubule dynamics. MCAK, a Kinesin-13, catalytically depolymerizes microtubules, regulates physiological microtubule dynamics, and is the major catastrophe factor in egg extracts. Purified GFP-tagged MCAK domain...

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Detalhes bibliográficos
Main Authors: Ems-McClung, Stephanie C., Hertzer, Kathleen M., Zhang, Xin, Miller, Mill W., Walczak, Claire E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751331/
https://ncbi.nlm.nih.gov/pubmed/17093055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-08-0724
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