The Interplay of the N- and C-Terminal Domains of MCAK Control Microtubule Depolymerization Activity and Spindle Assembly

Spindle assembly and accurate chromosome segregation require the proper regulation of microtubule dynamics. MCAK, a Kinesin-13, catalytically depolymerizes microtubules, regulates physiological microtubule dynamics, and is the major catastrophe factor in egg extracts. Purified GFP-tagged MCAK domain...

Full description

Saved in:
Bibliographic Details
Main Authors: Ems-McClung, Stephanie C., Hertzer, Kathleen M., Zhang, Xin, Miller, Mill W., Walczak, Claire E.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2007
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751331/
https://ncbi.nlm.nih.gov/pubmed/17093055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-08-0724
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items