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Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration

The asymmetric distribution of microtubule (MT) dynamics in migrating cells is important for cell polarization, yet the underlying regulatory mechanisms remain underexplored. Here, we addressed this question by studying the role of the MT depolymerase, MCAK (mitotic centromere-associated kinesin), i...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Zong, Hailing, Hazelbaker, Mark, Moe, Christina, Ems-McClung, Stephanie C., Hu, Ke, Walczak, Claire E.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101467/
https://ncbi.nlm.nih.gov/pubmed/33566676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-05-0301
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