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Determination of complete chromosomal haplotypes by bulk DNA sequencing
Haplotype phase represents the collective genetic variation between homologous chromosomes and is an essential feature of non-haploid genomes. Here we describe a computational strategy to reliably determine complete whole-chromosome haplotypes using a combination of bulk long-range sequencing and Hi...
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| Veröffentlicht in: | Genome Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8101039/ https://ncbi.nlm.nih.gov/pubmed/33957932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02330-1 |
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